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Version: 17.06d (Release date: 2017-06-26)
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Rhizoxin (Code C1218)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Rhizoxin

Definition: A macrocyclic lactone. Rhizoxin binds to tubulin and inhibits microtubule assembly, thereby inducing cytotoxicity. This agent also may inhibit endothelial cell-induced angiogenic activity, which may result in decreased tumor cell proliferation. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It comes from a fungus and is similar to vinca alkaloid drugs. It belongs to the family of drugs called antimitotic agents.

Label: Rhizoxin

NCI Thesaurus Code: C1218 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0073184  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Rhizoxin
rhizoxin
WF-1360

External Source Codes: 
CAS Registry Number 90996-54-6 (see NLM ChemIDplus info)
NSC Code 332598 (see NCI DTP info)
PDQ Closed Trial Search ID 41718
PDQ Open Trial Search ID 41718 (check for NCI PDQ open clinical trial info)
UMLS CUI C0073184

Other Properties:
     Name Value (qualifiers indented underneath)
code C1218
Legacy_Concept_Name Rhizoxin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1218

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