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Version: 17.10e (Release date: 2017-10-30)
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Adenosine A2A Receptor Antagonist PBF-509 (Code C121664)

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Terms & Properties

Preferred Name: Adenosine A2A Receptor Antagonist PBF-509

Definition: An orally bioavailable adenosine A2A receptor (A2AR) antagonist, with potential antineoplastic activity. Upon administration, A2AR antagonist PBF-509 selectively binds to and inhibits A2AR expressed on T-lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits their proliferation and activation. Adenosine is often produced in excess by cancer cells.

Display Name: Adenosine A2A Receptor Antagonist PBF-509

Label: Adenosine A2A Receptor Antagonist PBF-509

NCI Thesaurus Code: C121664 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C4053608  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
A2AR Antagonist PBF-509
Adenosine A2A Receptor Antagonist PBF-509

External Source Codes: 
PDQ Closed Trial Search ID 770798
PDQ Open Trial Search ID 770798 (check for NCI PDQ open clinical trial info)
UMLS CUI C4053608

Other Properties:
     Name Value (qualifiers indented underneath)
code C121664
Contributing_Source CTRP
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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