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Version: 17.05e (Release date: 2017-05-30)
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Agonistic Anti-CD40 Monoclonal Antibody ADC-1013 (Code C121538)

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Terms & Properties

Preferred Name: Agonistic Anti-CD40 Monoclonal Antibody ADC-1013

Definition: A human immunoglobulin (Ig) G1 monoclonal antibody directed against the cell surface receptor CD40 with potential immunostimulatory and antineoplastic activities. Upon intratumoral administration, agonistic anti-CD40 monoclonal antibody ADC-1013 binds to CD40 on antigen-presenting dendritic cells, which leads to the activation and proliferation of effector and memory T-cells, and enhances the immune response against tumor cells. In addition, this agent binds to the CD40 antigen present on the surfaces of tumor cells, which induces antibody-dependent cytotoxicity (ADCC). This eventually inhibits the proliferation of CD40-expressing tumor cells. CD40, a stimulatory receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on various immune cells, such as macrophages, dendritic cells and various tumor cell types; it plays a key role in the activation of the immune system.

Label: Agonistic Anti-CD40 Monoclonal Antibody ADC-1013

NCI Thesaurus Code: C121538 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL494041  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ADC-1013
Agonistic Anti-CD40 Monoclonal Antibody ADC-1013

External Source Codes: 
PDQ Closed Trial Search ID 770043
PDQ Open Trial Search ID 770043 (check for NCI PDQ open clinical trial info)
NCI META CUI CL494041

Other Properties:
     Name Value (qualifiers indented underneath)
code C121538
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=Thesaurus&code=C121538

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