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Version: 17.08d (Release date: 2017-08-28)
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Resiniferatoxin (Code C1214)

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Terms & Properties

Preferred Name: Resiniferatoxin

Definition: A naturally occurring capsaicin analog found in the latex of the cactus Euphorbia resinifera with analgesic activity. Resiniferatoxin (RTX) binds to and activates the transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel in the plasma membrane of primary afferent sensory neurons. This increases the permeability to cations, and leads to an influx of calcium and sodium ions. This results in membrane depolarization, causing an irritant effect, followed by desensitization of the sensory neurons thereby inhibiting signal conduction in afferent pain pathways and causing analgesia. TRPV1, a member of the transient receptor potential channel (TRP) superfamily, is a heat- and chemo-sensitive calcium/sodium ion channel that is selectively expressed in a subpopulation of pain-sensing primary afferent neurons.

Label: Resiniferatoxin

NCI Thesaurus Code: C1214 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0073081  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 57444-62-9 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 630743
PDQ Open Trial Search ID 630743 (check for NCI PDQ open clinical trial info)
UMLS CUI C0073081

Other Properties:
     Name Value (qualifiers indented underneath)
code C1214
Legacy_Concept_Name Resiniferatoxin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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