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Version: 17.06d (Release date: 2017-06-26)
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Pegaspargase (Code C1200)

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Terms & Properties

Preferred Name: Pegaspargase

Definition: A complex of polyethylene glycol conjugated with L-asparaginase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting these cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle. The agent also induces apoptosis in tumor cells. Pegylation decreases the enzyme's antigenicity. Asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. (NCI04)

NCI-GLOSS Definition: A drug used to treat acute lymphoblastic leukemia (ALL). It is a form of the drug asparaginase that is linked to a substance called PEG, which makes the drug stay in the body longer. Asparaginase is an enzyme that breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow. It is a type of protein synthesis inhibitor.

Display Name: Pegaspargase

Label: Pegaspargase

NCI Thesaurus Code: C1200 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0071568  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(Monomethoxypolyethylene Glycol Succinimidyl)74-L-Asparaginase
L-Asparaginase with Polyethylene Glycol
Oncaspar
PEG-Asparaginase
PEG-asparaginase
PEG-L-Asparaginase
PEG-L-Asparaginase (Enzon - Kyowa Hakko)
Pegaspargase
pegaspargase
PEGASPARGASE
PEGLA
Polyethylene Glycol-L-Asparaginase
Polyethylene Glycol L-Asparaginase

External Source Codes: 
CAS Registry Number 130167-69-0 (see NLM ChemIDplus info)
FDA UNII Code 7D96IR0PPM
NSC Code 624239 (see NCI DTP info)
NSC Code 644954 (see NCI DTP info)
PDQ Closed Trial Search ID 40312
PDQ Open Trial Search ID 40312 (check for NCI PDQ open clinical trial info)
UMLS CUI C0071568

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acute lymphoblastic leukemia
code C1200
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Pegaspargase
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1200

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