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Version: 17.12d (Release date: 2017-12-26)
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Poly ICLC (Code C1198)

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Terms & Properties

Preferred Name: Poly ICLC

Definition: A synthetic complex of carboxymethylcellulose, polyinosinic-polycytidylic acid, and poly-L-lysine double-stranded RNA. Poly ICLC may stimulate the release of cytotoxic cytokines and, by inducing interferon-gamma production, may increase the tumoricidal activities of various immunohematopoietic cells. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer and for its ability to stimulate the immune system. It is made in the laboratory by combining the nucleic acid RNA with the chemicals poly-L-lysine and carboxymethyl cellulose.

Display Name: Poly ICLC

Label: Poly ICLC

NCI Thesaurus Code: C1198 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0071359  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Poly I:Poly C with Poly-L-Lysine Stabilizer
PolyI:PolyC with Poly-L-Lysine Stabilizer
Polyinosinic-Polycytidylic Acid Stabilized with Polylysine and Carboxymethylcellulose
Polyriboinosinic-Polyribocytidylic Acid-Polylysine Carboxymethylcellulose
Stabilized Polyriboinosinic/Polyribocytidylic Acid

External Source Codes: 
CAS Registry Number 59789-29-6 (see NLM ChemIDplus info)
NSC Code 301463 (see NCI DTP info)
PDQ Closed Trial Search ID 39559
PDQ Open Trial Search ID 39559 (check for NCI PDQ open clinical trial info)
UMLS CUI C0071359

Other Properties:
     Name Value (qualifiers indented underneath)
code C1198
Contributing_Source CTRP
Legacy_Concept_Name Poly_ICLC
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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