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Version: 17.06d (Release date: 2017-06-26)
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Pirarubicin (Code C1197)

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Terms & Properties

Preferred Name: Pirarubicin

Definition: An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. (NCI04)

Label: Pirarubicin

NCI Thesaurus Code: C1197 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0071126  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2"R)-4'-O-Tetrahydropyranyladriamycin
(8S,10S)-10-[[3-Amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-3-yl)-alpha-L-lyxo-hexopyranosyl]oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
1609RB
4'-O-Tetrahydropyranyl Doxorubicin
[8S-[8Alpha,10alpha(S*)]]-10-[[3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
Pinorubicin
Pirarubicin
PIRARUBICIN
Tepirubicin
Tetrahydropyranyl-Doxorubicin
Theprubicin
Theprubicine
Therarubicin
THP-ADM
THP-Adriamycin
THP-DOX
THP-Doxorubicin

External Source Codes: 
CAS Registry Number 72496-41-4 (see NLM ChemIDplus info)
FDA UNII Code D58G680W0G
NSC Code 333054 (see NCI DTP info)
PDQ Closed Trial Search ID 38775
PDQ Open Trial Search ID 38775 (check for NCI PDQ open clinical trial info)
UMLS CUI C0071126

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C32H37NO12
code C1197
Contributing_Source FDA
Legacy_Concept_Name Pirarubicin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1197

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