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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Pimonidazole (Code C1196)

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Terms & Properties

Preferred Name: Pimonidazole

Definition: A 2-nitroimidazole with hypoxic selectivity and potential radiosensitizing activities. Pimonidazole is reduced in hypoxic environments such as those found in tumors. In hypoxic cells, reduced pimonidazole binds to thiol-containing proteins. The resulting complexes accumulate in hypoxic tumors, thereby depleting radioprotective thiol compounds and sensitizing tumor cells to be more susceptible for radiation treatment.

Label: Pimonidazole

NCI Thesaurus Code: C1196 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0071072  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-piperidineethanol, alpha-((2-nitro-1h-imidazol-1-yl)methyl)-
PD 126675
Ro 03-8799

External Source Codes: 
CAS Registry Number 70132-51-3 (see NLM ChemIDplus info)
FDA UNII Code 46JO4D76R2
NSC Code 380540 (see NCI DTP info)
PDQ Closed Trial Search ID 40356
PDQ Open Trial Search ID 40356 (check for NCI PDQ open clinical trial info)
UMLS CUI C0071072

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C11H18N4O3
code C1196
Contributing_Source FDA
Legacy_Concept_Name Pimonidazole
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  


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