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Version: 17.06d (Release date: 2017-06-26)
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Penclomedine (Code C1188)

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Terms & Properties

Preferred Name: Penclomedine

Definition: A synthetic derivative of pyrimidine with antineoplastic activity. Penclomedine alkylates and crosslinks DNA, resulting in DNA strand breaks and inhibition of DNA and RNA synthesis. This agent is more active against tumor cells that are defective in p53 function. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called alkylating agents.

Label: Penclomedine

NCI Thesaurus Code: C1188 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0070220  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl) pyridine
CRC 88-04
PEN
Penclomedine
penclomedine
PENCLOMEDINE
Pyridine, 3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl)-

External Source Codes: 
CAS Registry Number 108030-77-9 (see NLM ChemIDplus info)
FDA UNII Code 66Q80IL7CW
NSC Code 338720 (see NCI DTP info)
PDQ Closed Trial Search ID 41973
PDQ Open Trial Search ID 41973 (check for NCI PDQ open clinical trial info)
UMLS CUI C0070220

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C8H6Cl5NO2
code C1188
Contributing_Source FDA
Legacy_Concept_Name Penclomedine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1188

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