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Version: 17.02d (Release date: 2016-02-27)
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Activin Type 2B Receptor Fc Fusion Protein STM 434 (Code C118625)

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Terms & Properties

Preferred Name: Activin Type 2B Receptor Fc Fusion Protein STM 434

Definition: A soluble fusion protein containing the extracellular domain of the activin receptor type 2B (ACVR2B or ActRIIB) fused to a human Fc domain, with potential antineoplastic activity. Upon intravenous administration, STM 434 selectively binds to the growth factor activin A, thereby preventing its binding to and the activation of endogenous ActRIIB. This prevents activin A/ActRIIB-mediated signaling and inhibits the proliferation of activin A-overexpressing tumor cells. Activin A, a member of the transforming growth factor beta (TGF-beta) superfamily, is overexpressed in a variety of cancers and plays a key role in promoting cancer cell proliferation, migration, and survival.

Display Name: Activin Type 2B Receptor Fc Fusion Protein STM 434

Label: Activin Type 2B Receptor Fc Fusion Protein STM 434

NCI Thesaurus Code: C118625 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3896763  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Activin Inhibitor STM 434
Activin Type 2B Receptor Fc Fusion Protein STM 434
STM 434

External Source Codes: 
PDQ Closed Trial Search ID 765514
PDQ Open Trial Search ID 765514 (check for NCI PDQ open clinical trial info)
UMLS CUI C3896763

Other Properties:
Name Value (qualifiers indented underneath)
code C118625
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C118625

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