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Version: 17.06d (Release date: 2017-06-26)
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Ranpirnase (Code C1183)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ranpirnase

Definition: A natural homologue of ribonuclease A isolated from the eggs of the frog Rana pipiens. Ranpirnase primarily degrades cellular transfer RNA with a substrate specificity for uridine-guanidine base-pair sequences, resulting in inhibition of protein synthesis and cytotoxicity. This agent also activates caspase-9 in mitochondria, resulting in tumor cell apoptosis. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It is a type of ribonuclease enzyme.

Label: Ranpirnase

NCI Thesaurus Code: C1183 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0069919  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Onconase
P-30
P-30 Protein
P-30 protein
P30
P30 Protein
Ranpirnase

External Source Codes: 
CAS Registry Number 196488-72-9 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 41305
PDQ Open Trial Search ID 41305 (check for NCI PDQ open clinical trial info)
UMLS CUI C0069919

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Mesothelioma
code C1183
Legacy_Concept_Name Ranpirnase
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1183

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