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Version: 17.06d (Release date: 2017-06-26)
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Piroxantrone (Code C1182)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Piroxantrone

Definition: An anthrapyrazole antineoplastic antibiotic. Piroxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Although less cardiotoxic than doxorubicin, this agent exhibits a narrow spectrum of antineoplastic activity. (NCI04)

Label: Piroxantrone

NCI Thesaurus Code: C1182 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0069736  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anthra(1,9-cd)pyrazol-6(2H)-one, 5-((3-aminopropyl)amino)-7,10-dihydroxy-2-(2-((2-hydroxyethyl)amino)ethyl)
CI-942
Oxanthrazole
Oxantrazole
PD-111815
PIROXANTRONE
Piroxantrone
Piroxantrone HCl

External Source Codes: 
CAS Registry Number 91441-23-5 (see NLM ChemIDplus info)
FDA UNII Code YL4TY9WH22
NSC Code 349174 (see NCI DTP info)
PDQ Closed Trial Search ID 40791
PDQ Open Trial Search ID 40791 (check for NCI PDQ open clinical trial info)
UMLS CUI C0069736

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H25N5O4
code C1182
Contributing_Source FDA
Legacy_Concept_Name Piroxantrone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1182

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