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Version: 17.06d (Release date: 2017-06-26)
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Oxaliplatin (Code C1181)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Oxaliplatin

Definition: An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance. (NCI04)

NCI-GLOSS Definition: A drug used with other drugs to treat colorectal cancer that is advanced or has come back. It is also being studied in the treatment of other types of cancer. Eloxatin attaches to DNA in cells and may kill cancer cells. It is a type of platinum compound.

Display Name: Oxaliplatin

Label: Oxaliplatin

NCI Thesaurus Code: C1181 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0069717  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-OHP
[(1R,-2R)-1,2-cyclohexanediamine-N,N'][oxalato (2--)-O,O']platinum
[SP-4-2-(1R-trans)]-(1,2,cyclohexanediamine-N,N')[ethanedioato(2--)-O,O']platinum
Aiheng
Ai Heng
Dacotin
Dacplat
DACPLAT
Diaminocyclohexane Oxalatoplatinum
Eloxatin
ELOXATIN
Eloxatine
JM-83
Oxalatoplatin
Oxalatoplatinum
oxalato (1R,2R-cyclohexanediamine)platinum(II)
oxalato (trans-l-1,2-diaminocyclohexane)platinum(II)
Oxaliplatin
OXALIPLATIN
oxaliplatin
RP-54780
RP 54780
SR-96669
trans-l DACH oxalatoplatinum
trans-l diaminocyclohexane oxalatoplatinum

External Source Codes: 
CAS Registry Number 61825-94-3 (see NLM ChemIDplus info)
FDA UNII Code 04ZR38536J
ChEBI ID CHEBI:31941 (see ChEBI info)
NSC Code 266046 (see NCI DTP info)
PDQ Closed Trial Search ID 42374
PDQ Open Trial Search ID 42374 (check for NCI PDQ open clinical trial info)
UMLS CUI C0069717

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Metastatic colorectal cancer; ovarian cancer
Chemical_Formula C8H14N2O4Pt
code C1181
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Oxaliplatin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1181

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