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Version: 17.06d (Release date: 2017-06-26)
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Tilarginine (Code C1178)

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Terms & Properties

Preferred Name: Tilarginine

Definition: An amino acid derivative with potential antineoplastic activity. NG-monomethyl-L-arginine inhibits the enzyme nitric oxide synthase, resulting in a diminution of nitrous oxide production. This agent may inhibit tumor angiogenesis. (NCI04)

NCI-GLOSS Definition: An amino acid derivative used to counteract high blood pressure caused by interleukin-2.

Label: Tilarginine

NCI Thesaurus Code: C1178 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0069477  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
N-Methylarginine
N5-(Methylamidino)-L-ornithine
NG-Monomethyl-L-Arginine
NG-monomethyl-L-arginine
NMA
omega-N-Monomethylarginine
Targinine
Tilarginine
TILARGININE

External Source Codes: 
CAS Registry Number 17035-90-4 (see NLM ChemIDplus info)
FDA UNII Code 27JT06E6GR
ChEBI ID CHEBI:28229 (see ChEBI info)
NSC Code 683245 (see NCI DTP info)
PDQ Closed Trial Search ID 42258
PDQ Open Trial Search ID 42258 (check for NCI PDQ open clinical trial info)
UMLS CUI C0069477

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C7H16N4O2
code C1178
Contributing_Source FDA
Legacy_Concept_Name NG-Monomethyl-L-Arginine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1178

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