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Version: 17.05e (Release date: 2017-05-30)
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Agonistic Anti-OX40 Monoclonal Antibody MEDI6469 (Code C117293)

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Terms & Properties

Preferred Name: Agonistic Anti-OX40 Monoclonal Antibody MEDI6469

Definition: An agonistic monoclonal antibody against the co-stimulatory receptor OX40 (CD134), with potential immunostimulatory and antineoplastic activities. Upon intravenous administration, anti-OX40 monoclonal antibody MEDI6469 selectively binds to and activates OX40. OX40 activation induces proliferation of effector T-lymphocytes. In the presence of tumor-associated antigens (TAAs), this may promote an immune response against the TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on T-lymphocytes and provides a co-stimulatory signal for the proliferation and survival of activated T-cells.

Label: Agonistic Anti-OX40 Monoclonal Antibody MEDI6469

NCI Thesaurus Code: C117293 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL474118  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Agonistic Anti-CD134 Monoclonal Antibody MEDI6469
Agonistic Anti-OX40 Monoclonal Antibody MEDI6469
MEDI6469

External Source Codes: 
PDQ Closed Trial Search ID 763664
PDQ Open Trial Search ID 763664 (check for NCI PDQ open clinical trial info)
NCI META CUI CL474118

Other Properties:
     Name Value (qualifiers indented underneath)
code C117293
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=Thesaurus&code=C117293

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