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Version: 16.11d (Release date: 2016-11-28)
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Miltefosine (Code C1170)

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Terms & Properties

Preferred Name: Miltefosine

Definition: An orally- and topically-active alkyl-phosphocholine compound with potential antineoplastic activity. Miltefosine targets cellular membranes, modulating cell membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. As an immunomodulator, miltefosine stimulates T-cells, macrophages and the expression of interleukin 3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF), and interferon gamma (INF-gamma). (NCI04)

Label: Miltefosine

NCI Thesaurus Code: C1170 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0068006  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-[[(Hexadecycloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium Inner Salt
Choline Phosphate Hexadecyl Ester, Hydroxide, Inner Salt
D-18506
Hexadecylphosphocholine
Hexadecyl 2-(N,N,N-trimethylamino)ethyl Phosphate
Miltefosin
Miltefosina
MILTEFOSINE
Miltefosine
Miltefosinum
Miltex
n-Hexadecylphosphorylcholine

External Source Codes: 
CAS Registry Number 58066-85-6 (see NLM ChemIDplus info)
FDA UNII Code 53EY29W7EC
PDQ Closed Trial Search ID 41212
PDQ Open Trial Search ID 41212 (check for NCI PDQ open clinical trial info)
UMLS CUI C0068006

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Skin metastasis of breast cancer
Chemical_Formula C21H46NO4P
code C1170
Contributing_Source FDA
Legacy_Concept_Name Miltefosine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1170

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