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Version: 17.05e (Release date: 2017-05-30)
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ALK5 Inhibitor TEW-7197 (Code C116357)

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Terms & Properties

Preferred Name: ALK5 Inhibitor TEW-7197

Definition: An orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potential antineoplastic activity. Upon oral administration, ALK5 inhibitor TEW-7197 inhibits the activity of TGFBR1 and prevents TGF-beta/TGFBR1-mediated signaling. This suppresses tumor growth in TGFBR1-overexpressing tumor cells. TGFBR1, which is overexpressed in a variety of tumor cell types, plays a key role in tumor cell proliferation. Expression of TGF-beta promotes tumor cell proliferation, enhances the migration of tumor cells and suppresses the response of the host immune system to tumor cells.

Label: ALK5 Inhibitor TEW-7197

NCI Thesaurus Code: C116357 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL473674  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ALK5 Inhibitor TEW-7197
TGFBR1 Inhibitor TEW-7197

External Source Codes: 
PDQ Closed Trial Search ID 762093
PDQ Open Trial Search ID 762093 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C116357
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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