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Version: 17.06d (Release date: 2017-06-26)
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siRNA-transfected Peripheral Blood Mononuclear Cells APN401 (Code C116353)

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Terms & Properties

Preferred Name: siRNA-transfected Peripheral Blood Mononuclear Cells APN401

Definition: Autologous peripheral blood mononuclear cells (PBMCs) transfected ex vivo with small-interfering ribonucleic acid (siRNA) directed against the E3 ubiquitin ligase casitas B-lineage lymphoma-b gene (Cbl-b), with potential immunoactivating and antineoplastic activities. The Cbl-b gene is silenced ex vivo through the binding of Cbl-b siRNA to Cbl-b mRNA, which prevents the translation of the Cbl-b protein in T-lymphocytes. Upon infusion, the activated, Cbl-b-silenced T-lymphocytes are able to increase the production of cytokines, proliferate and activate the immune system, which leads to cancer cell eradication. Cbl-b, a negative regulator of the immune system, is mutated in a variety of cancer cell types. Its expression is inversely correlated with activation of T-lymphocytes and tumor cell eradication.

Label: siRNA-transfected Peripheral Blood Mononuclear Cells APN401

NCI Thesaurus Code: C116353 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL473671  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
siRNA-transfected PBMC APN401
siRNA-transfected Peripheral Blood Mononuclear Cells APN401

External Source Codes: 
PDQ Closed Trial Search ID 761870
PDQ Open Trial Search ID 761870 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C116353
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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