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Version: 17.06d (Release date: 2017-06-26)
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Liposomal Curcumin (Code C116322)

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Terms & Properties

Preferred Name: Liposomal Curcumin

Definition: A liposomal formulation containing curcumin, a poorly water-soluble polylphenol pigment isolated from the plant Curcuma longa, with potential antineoplastic, chemopreventive, antioxidant, anti-angiogenic and anti-inflammatory activities. Upon intravenous administration of liposomal curcumin, this agent blocks the formation of reactive-oxygen species, neutralizes free radicals, and exhibits anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation. In addition, curcumin disrupts various cell signal transduction pathways involved in carcinogenesis, inhibits the activity of nuclear factor-kappa B (NF-kB), SRC, and annexin A2 (ANXA2), and reduces the expression of both matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor receptor 2 (VEGFR2). This prevents and/or inhibits tumor cell formation and proliferation. Liposome encapsulation of curcumin improves its efficacy, when compared to the administration of unencapsulated curcumin.

Label: Liposomal Curcumin

NCI Thesaurus Code: C116322 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL473656  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Curcumin Liposome
Liposomal Curcumin

External Source Codes: 
PDQ Closed Trial Search ID 761276
PDQ Open Trial Search ID 761276 (check for NCI PDQ open clinical trial info)
NCI META CUI CL473656

Other Properties:
     Name Value (qualifiers indented underneath)
code C116322
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C116322

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