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Version: 17.06d (Release date: 2017-06-26)
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CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine (Code C116321)

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Terms & Properties

Preferred Name: CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine

Definition: A plasmid DNA vaccine containing the mammalian expression vector pUMVC3 (pNGVL3) encoding epitopes of CD105 (Endoglin), Y-box binding protein 1 (Yb-1), SRY-box 2 (SOX2), cadherin 3 (CDH3), and murine double minute 2 (MDM2) proteins, with potential immunomodulating and antineoplastic activities. Upon intradermal administration of pUMVC3-CD105/Yb-1/SOX2/CDH3/MDM2-epitopes plasmid DNA vaccine, the plasmid transfects cells and the peptides are expressed. This generates a specific memory Th1 (T-helper) cell immune response, stimulates secretion of cytokines by the T cells and leads to a cytotoxic T-lymphocyte (CTL) response against CD105/Yb-1/SOX2/CDH3/MDM2-expressing tumor cells. CD105/Yb-1/SOX2/CDH3/MDM2 proteins are highly immunogenic tumor associated antigens that are overexpressed in breast cancer. Additionally, these antigens are associated with breast cancer stem cells and with epithelial to mesenchymal transformation (EMT).

Label: CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine

NCI Thesaurus Code: C116321 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL473655  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine
CD105/Yb-1/SOX2/CDH3/MDM2 Plasmid Vaccine
STEMVAC
STEMVAC Th1 Polyepitope Plasmid-based Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 761274
PDQ Open Trial Search ID 761274 (check for NCI PDQ open clinical trial info)
NCI META CUI CL473655

Other Properties:
     Name Value (qualifiers indented underneath)
code C116321
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C116321

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