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Version: 17.06d (Release date: 2017-06-26)
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Metoprine (Code C1161)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Metoprine

Definition: A diaminopyrimidine folate antagonist with potential antineoplastic activity. Metoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism and cell growth; it also inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble metoprine is capable of crossing the blood-brain barrier. (NCI04)

Label: Metoprine

NCI Thesaurus Code: C1161 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0066142  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BW 197U
DDMP
Metoprine
METOPRINE

External Source Codes: 
CAS Registry Number 7761-45-7 (see NLM ChemIDplus info)
FDA UNII Code 2L9RKX796Q
NSC Code 7364 (see NCI DTP info)
NSC Code 19494 (see NCI DTP info)
PDQ Closed Trial Search ID 39206
PDQ Open Trial Search ID 39206 (check for NCI PDQ open clinical trial info)
UMLS CUI C0066142

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C11H10Cl2N4
code C1161
Contributing_Source FDA
Legacy_Concept_Name Metoprine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1161

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