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Version: 17.06d (Release date: 2017-06-26)
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Iodine I 124 CPD-1028 (Code C116071)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Iodine I 124 CPD-1028

Definition: A radioconjugate composed of the insulin-like growth factor 1 receptor (IGF-1R) binding agent CPD-1028 and conjugated to the radionuclide iodine I 124, with potential tumor imaging upon positron emission tomography/computed tomography (PET/CT). Upon administration, iodine I 124 CPD-1028 targets and binds to IGF-1R-expressing tumor cells. Upon PET/CT imaging, the iodine I 124 moiety can be visualized and the quantity of IGF-1R-expressing tumor cells can be assessed. IGF-1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a significant role in the stimulation of cellular proliferation, oncogenic transformation, and the suppression of apoptosis.

Label: Iodine I 124 CPD-1028

NCI Thesaurus Code: C116071 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL473490  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
[I-124]-CPD-1028
Iodine I 124 CPD-1028

External Source Codes: 
PDQ Closed Trial Search ID 761119
PDQ Open Trial Search ID 761119 (check for NCI PDQ open clinical trial info)
NCI META CUI CL473490

Other Properties:
     Name Value (qualifiers indented underneath)
code C116071
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C116071

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