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Version: 17.06d (Release date: 2017-06-26)
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Liposomal Mitoxantrone Hydrochloride (Code C116064)

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Terms & Properties

Preferred Name: Liposomal Mitoxantrone Hydrochloride

Definition: A formulation composed of the hydrochloride salt form of the anthracenedione antibiotic mitoxantrone encapsulated within liposomes, with potential antineoplastic activity. Upon intravenous administration, mitoxantrone intercalates into and forms crosslinks with DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, which both results in DNA strand breaks and prevents DNA synthesis. This leads to the induction of apoptosis in the rapidly dividing cancer cells. The liposomal delivery of mitoxantrone improves drug penetration into tumors and decreases drug clearance, thereby increasing drug circulation and therapeutic efficacy while lowering the toxic effects.

Label: Liposomal Mitoxantrone Hydrochloride

NCI Thesaurus Code: C116064 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL473483  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Liposomal Mitoxantrone Hydrochloride
Mitoxantrone Hydrochloride Liposome

External Source Codes: 
PDQ Closed Trial Search ID 760808
PDQ Open Trial Search ID 760808 (check for NCI PDQ open clinical trial info)
NCI META CUI CL473483

Other Properties:
     Name Value (qualifiers indented underneath)
code C116064
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C116064

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