skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Indium In 111-DOTA-exendin-4 (Code C115981)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Indium In 111-DOTA-exendin-4

Definition: A radiopharmaceutical composed of the glucagon-like peptide 1 receptor (GLP-1R) agonist exendin-4 linked by the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the positron-emitting radionuclide indium In 111, with potential use in diagnostic imaging upon positron emission tomography (PET). Upon administration of indium In 111-DOTA-exendin-4, the exendin-4 moiety binds to GLP-1R and is subsequently internalized. The radionuclide moiety can be detected using PET and GLP-1R-expressing tumors can be localized. GLP-1R, located on beta cells, is overexpressed on insulinomas, which are insulin-secreting neuroendocrine tumors.

Label: Indium In 111-DOTA-exendin-4

NCI Thesaurus Code: C115981 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL473313  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Indium In 111-DOTA-exendin-4

External Source Codes: 
PDQ Closed Trial Search ID 760679
PDQ Open Trial Search ID 760679 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C115981
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom