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Version: 17.06d (Release date: 2017-06-26)
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Gallium Ga 68-DOTA-exendin-4 (Code C115980)

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Terms & Properties

Preferred Name: Gallium Ga 68-DOTA-exendin-4

Definition: A radiopharmaceutical composed of the glucagon-like peptide 1 receptor (GLP-1R) agonist exendin-4 linked by the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the positron-emitting radionuclide gallium Ga 68, with potential use in diagnostic imaging upon positron emission tomography (PET). Upon administration of gallium Ga 68-DOTA-exendin-4, the exendin-4 moiety binds to GLP-1R and is subsequently internalized. The radionuclide moiety can be detected using PET and GLP-1R-expressing tumors can be localized. GLP-1R, located on beta cells, is overexpressed on insulinomas, which are insulin-secreting neuroendocrine tumors.

Label: Gallium Ga 68-DOTA-exendin-4

NCI Thesaurus Code: C115980 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL473312  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Gallium Ga 68-DOTA-exendin-4

External Source Codes: 
PDQ Closed Trial Search ID 760678
PDQ Open Trial Search ID 760678 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C115980
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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