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Version: 17.06d (Release date: 2017-06-26)
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HLA-DP0401/0402-Restricted MAGE-A3-Reactive T Cell Receptor-transduced Autologous T Cells (Code C115979)

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Terms & Properties

Preferred Name: HLA-DP0401/0402-Restricted MAGE-A3-Reactive T Cell Receptor-transduced Autologous T Cells

Definition: Human autologous T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-DP0401/0402-restricted, melanoma antigen A3 (MAGE-A3), with potential antineoplastic activity. CD4-positive cells are isolated from a patient, transduced with an anti-MAGE-A3-DP0401/0402 restricted TCR, expanded ex vivo, and reintroduced into the HLA-DP0401/0402 positive patient. Then, the HLA-DP0401/0402-restricted, MAGE-A3-reactive TCR-transduced autologous T cells bind to tumor cells expressing the MAGE-A3 antigen, which may result in both an inhibition of growth and increased cell death for MAGE-A3-expressing cancer cells. The tumor-associated antigen MAGE-A3 is overexpressed by a variety of cancer cell types.

Label: HLA-DP0401/0402-Restricted MAGE-A3-Reactive T Cell Receptor-transduced Autologous T Cells

NCI Thesaurus Code: C115979 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL473311  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-MAGE-A3-DP4 TCR PBL
HLA-DP0401/0402-Restricted MAGE-A3-Reactive T Cell Receptor-transduced Autologous T Cells

External Source Codes: 
PDQ Closed Trial Search ID 760677
PDQ Open Trial Search ID 760677 (check for NCI PDQ open clinical trial info)
NCI META CUI CL473311

Other Properties:
     Name Value (qualifiers indented underneath)
code C115979
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C115979

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