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Version: 17.06d (Release date: 2017-06-26)
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Dendritic Cell-targeting Lentiviral Vector ID-LV305 (Code C115976)

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Terms & Properties

Preferred Name: Dendritic Cell-targeting Lentiviral Vector ID-LV305

Definition: An engineered lentiviral vector targeting dendritic cells (DCs) and containing nucleic acids encoding for the human tumor-associated cancer-testis antigen NY-ESO-1, with potential immunostimulatory and antineoplastic activities. Upon intradermal administration, the DC-targeting lentiviral vector ID-LV305 targets and binds to dermal DCs via the DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) receptor. Upon internalization of the vector, the NY-ESO-1 protein is expressed, stimulates DC maturation and activates the immune system to mount a cytotoxic T-lymphocyte (CTL) response against NY-ESO-1-expressing cells, which may result in tumor cell lysis. NY-ESO-1 is expressed in normal testes and on the surfaces of various tumor cells, and plays a key role in tumor cell proliferation and survival.

Label: Dendritic Cell-targeting Lentiviral Vector ID-LV305

NCI Thesaurus Code: C115976 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL473308  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DCvex-NY-ESO-1
Dendritic Cell-targeting Lentiviral Vector ID-LV305
ID-LV305

External Source Codes: 
PDQ Closed Trial Search ID 760531
PDQ Open Trial Search ID 760531 (check for NCI PDQ open clinical trial info)
NCI META CUI CL473308

Other Properties:
     Name Value (qualifiers indented underneath)
code C115976
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C115976

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