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Version: 17.06d (Release date: 2017-06-26)
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Hsp70-peptide TKD/IL-2-activated Autologous Natural Killer Cells (Code C115969)

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Terms & Properties

Preferred Name: Hsp70-peptide TKD/IL-2-activated Autologous Natural Killer Cells

Definition: A preparation of autologous natural killer (NK) cells that are stimulated ex vivo by a 14-mer heat shock protein 70 (Hsp70) TKD peptide and interleukin-2 (IL-2), with potential tumor-selective cytolytic activity. Upon re-infusion into the patient, the treated NK cells recognize and bind to Hsp70-expressing tumor cells, which induces NK-mediated tumor cell lysis. Hsp70, a membrane-bound, stress-inducible protein, is overexpressed on almost all tumor cells; however, it is absent or minimally present on normal, healthy cells. TKD is the C-terminal substrate-binding domain of Hsp70 and is the structure recognized by the activated NK cells.

Label: Hsp70-peptide TKD/IL-2-activated Autologous Natural Killer Cells

NCI Thesaurus Code: C115969 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL473303  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hsp70-peptide TKD/IL-2-activated Autologous Natural Killer Cells
Hsp70-peptide TKD/IL-2-activated Autologous NK Cells

External Source Codes: 
PDQ Closed Trial Search ID 760428
PDQ Open Trial Search ID 760428 (check for NCI PDQ open clinical trial info)
NCI META CUI CL473303

Other Properties:
     Name Value (qualifiers indented underneath)
code C115969
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C115969

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