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Version: 17.06d (Release date: 2017-06-26)
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Carrageenan-containing Gel (Code C115961)

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Terms & Properties

Preferred Name: Carrageenan-containing Gel

Definition: A water-based, vaginal moisturizing gel containing a mixture of lambda- and kappa- carrageenans, sulfated polysaccharides derived from red seaweed (Chondrus crispus), with potential microbicidal activity against various viruses, including human papillomavirus (HPV), human immunodeficiencyvirus (HIV) and human herpes simplex virus (HSV). Upon vaginal insertion via an applicator, carrageenan specifically binds to the viral capsids, which prevents the binding of virions to heparan sulfate proteoglycan (HSPG) receptors or other, as of yet not fully identified, cellular proteins. In addition, the viral binding of carrageenan may also interfere with conformational changes within the virions after cellular attachment. This inhibits viral infection. Certain HPV types cause cervical cancer; therefore, the prevention of HPV infection by this gel may subsequently prevent the development of cervical cancer.

Label: Carrageenan-containing Gel

NCI Thesaurus Code: C115961 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL473298  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Carrageenan-containing Gel
Divine 9 with Carragel

External Source Codes: 
PDQ Closed Trial Search ID 760314
PDQ Open Trial Search ID 760314 (check for NCI PDQ open clinical trial info)
NCI META CUI CL473298

Other Properties:
     Name Value (qualifiers indented underneath)
code C115961
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C115961

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