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Version: 17.06d (Release date: 2017-06-26)
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Megestrol Acetate (Code C1156)

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Terms & Properties

Preferred Name: Megestrol Acetate

Definition: The acetate salt form of megestrol, a synthetic derivative of the naturally occurring female sex hormone progesterone with potential anti-estrogenic and antineoplastic activity. Mimicking the action of progesterone, megestrol acetate binds to and activates nuclear progesterone receptors in the reproductive system, and causes the ligand-receptor complex to be translocated to the nucleus where it binds to and promotes expression of target genes. This leads to an alteration in protein synthesis, which modulates cell growth of reproductive tissues. Due to the negative feedback mechanism seen with progesterone, megestrol also blocks luteinizing hormone (LH) release from the pituitary gland, thereby leading to an inhibition of ovulation and an alteration in the cervical mucus and endometrium. Furthermore, without stimulation of LH, estrogen release from the ovaries is stopped, hence impedes the growth of estrogen-sensitive tumor cells.

NCI-GLOSS Definition: A drug used to block estrogen and suppress the effects of estrogen and androgens. It is used to treat breast and endometrial cancer, and is being studied in the treatment of other types of cancer. It is also used to improve appetite in patients with cancer. Megace belongs to the group of hormones called progestins.

Display Name: Megestrol Acetate

Label: Megestrol Acetate

NCI Thesaurus Code: C1156 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0065879  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(9beta,10alpha)-17-(Acetyloxy)-6-methylpregna-4,6-diene-3,20-dione
17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate
17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione Acetate
17.alpha.-Acetoxy-6-methylpregna-4,6-diene-3,20-dione
17 Alpha-acetoxy-6-methylpregna-4,6-diene-3,20-dione
6-Dehydro-6-methyl-17.alpha.-acetoxyprogesterone
6-Dehydro-6-methyl-17 alpha-acetoxyprogesterone
6-Methyl-6-dehydro-17.alpha.-acetoxyprogesterone
6-Methyl-delta-4,6-pregnadien-17 alpha-ol-3,20-dione Acetate
BDH-1298
BDH 1298
Maygace
Megace
Megestat
Megestil
Megestrol Acetate
MEGESTROL ACETATE
Niagestin
Ovaban
Pallace
SC-10363

External Source Codes: 
CAS Registry Number 595-33-5 (see NLM ChemIDplus info)
FDA UNII Code TJ2M0FR8ES
ChEBI ID CHEBI:6723 (see ChEBI info)
NSC Code 71423 (see NCI DTP info)
PDQ Closed Trial Search ID 43435
PDQ Open Trial Search ID 43435 (check for NCI PDQ open clinical trial info)
UMLS CUI C0065879

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Appetite enhancement, AIDS patients; Breast cancer, palliative treatment; Endometrial carcinoma, palliative treatment
Chemical_Formula C24H32O4
code C1156
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Megestrol_Acetate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1156

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