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Version: 17.08d (Release date: 2017-08-28)
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Dolasetron Mesylate (Code C1153)

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Terms & Properties

Preferred Name: Dolasetron Mesylate

Definition: An indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, dolasetron mesylate competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. (NCI04)

NCI-GLOSS Definition: A drug used to treat nausea and vomiting caused by cancer treatment. It is a type of serotonin receptor antagonist and a type of antiemetic.

Display Name: Dolasetron Mesylate

Label: Dolasetron Mesylate

NCI Thesaurus Code: C1153 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0065818  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Dolasetron Mesylate
dolasetron mesylate
MDL 73,147EF

External Source Codes: 
CAS Registry Number 115956-13-3 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 41354
PDQ Open Trial Search ID 41354 (check for NCI PDQ open clinical trial info)
UMLS CUI C0065818

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Nausea and vomiting prophylaxis, chemotherapy-induced and postoperative
Chemical_Formula C19H20N2O3.CH4O3S.H2O
code C1153
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Dolasetron_Mesylate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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