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Version: 17.06d (Release date: 2017-06-26)
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Marcellomycin (Code C1152)

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Terms & Properties

Preferred Name: Marcellomycin

Definition: An antineoplastic oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Actinosporangium bohemicum. Marcellomycin intercalates into DNA and induces DNA crosslinks, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also induces differentiation in HL-60 promyelocytic leukemia cells by interfering with glycoprotein synthesis. (NCI04)

Label: Marcellomycin

NCI Thesaurus Code: C1152 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0065718  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-Naphthacenecarboxylic acid, 4-[[O-2,6-dideoxy-alpha-L-lyxo-hexopyranosyl-(1-4)-O-2, 6-dideoxy-alpha-L-lyxo-hexopyranosyl-(1-4)-2,3, 6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy]-2-e thyl-1,2,3,4,6,11-hexahydro-2,5,7,10-tetrahydroxy-6,11-dioxo-, methyl ester, (1R-(1alpha,2beta,4beta))- (9CI)
Marcellomycin
MARCELLOMYCIN
Rhodirubin E

External Source Codes: 
CAS Registry Number 63710-10-1 (see NLM ChemIDplus info)
NSC Code 265211 (see NCI DTP info)
PDQ Closed Trial Search ID 39758
PDQ Open Trial Search ID 39758 (check for NCI PDQ open clinical trial info)
UMLS CUI C0065718

Other Properties:
     Name Value (qualifiers indented underneath)
code C1152
Legacy_Concept_Name Marcellomycin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1152

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