skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Galectin Inhibitor GR-MD-02 (Code C115111)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Galectin Inhibitor GR-MD-02

Definition: A carbohydrate-based galectin inhibitor, with potential antineoplastic activity. Galectin inhibitor GR-MD-02 binds to the carbohydrate-binding domain of galectins, especially galectin-3, and may result in an induction of apoptosis mediated through activation of both mitochondria and caspases. This may reduce tumor growth in galectin-overexpressing tumor cells. Galectins, often overexpressed on tumor cells, play a key role in cancer cell proliferation, apoptosis, tumor angiogenesis and evasion of immune responses.

Label: Galectin Inhibitor GR-MD-02

NCI Thesaurus Code: C115111 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL472642  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Galactoarabino-rhamnogalacturonate
Galectin Inhibitor GR-MD-02
GR-MD-02

External Source Codes: 
PDQ Closed Trial Search ID 760131
PDQ Open Trial Search ID 760131 (check for NCI PDQ open clinical trial info)
NCI META CUI CL472642

Other Properties:
     Name Value (qualifiers indented underneath)
code C115111
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C115111

Mainbox Bottom