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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Galectin Inhibitor GR-MD-02 (Code C115111)

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Terms & Properties

Preferred Name: Galectin Inhibitor GR-MD-02

Definition: A carbohydrate-based galectin inhibitor, with potential antineoplastic activity. Galectin inhibitor GR-MD-02 binds to the carbohydrate-binding domain of galectins, especially galectin-3, and may result in an induction of apoptosis mediated through activation of both mitochondria and caspases. This may reduce tumor growth in galectin-overexpressing tumor cells. Galectins, often overexpressed on tumor cells, play a key role in cancer cell proliferation, apoptosis, tumor angiogenesis and evasion of immune responses.

Label: Galectin Inhibitor GR-MD-02

NCI Thesaurus Code: C115111 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL472642  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Galectin Inhibitor GR-MD-02

External Source Codes: 
PDQ Closed Trial Search ID 760131
PDQ Open Trial Search ID 760131 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C115111
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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