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Version: 17.06d (Release date: 2017-06-26)
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Dioscorea nipponica Makino Extract DNE3 (Code C115103)

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Terms & Properties

Preferred Name: Dioscorea nipponica Makino Extract DNE3

Definition: An extract of the plant Dioscorea nipponica Makino and inhibitor of both the serine/threonine protein kinase Akt (protein kinase B) and members of the phosphatidylinositol 3-kinase (PI3K) family of lipid kinases, with potential antineoplastic and anti-metastatic activities. Dioscorea nipponica Makino extracted with ethyl acetate (DNE3) binds to and inhibits PI3K and Akt. This inhibits PI3K/Akt-mediated signaling and prevents both growth and survival of PI3K/Akt-overexpressing tumor cells. In addition, DNE3 increases the expression of tissue inhibitor of metalloproteinase-2 (TIMP-2), inhibits the secretion of matrix metalloproteinases (MMPs), primarily MMP-2 and MMP-9, and inhibits the serine protease urokinase (urokinase-type plasminogen activator; u-PA). This inhibits tumor cell invasion, migration, motility, and adhesion. This agent also inhibits the activation of both cAMP response element-binding (CREB) and activating protein-1 (AP-1), and increases the expression of IkappaB (IkB), which inhibits the activation of nuclear factor-kappa B (NF-kB). These processes further contribute to this agent's anti-tumor potential in susceptible tumor cells.

Label: Dioscorea nipponica Makino Extract DNE3

NCI Thesaurus Code: C115103 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL472634  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Dioscorea nipponica Extract with Ethyl Acetate
Dioscorea nipponica Makino Extract DNE3

External Source Codes: 
PDQ Closed Trial Search ID 759832
PDQ Open Trial Search ID 759832 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C115103
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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