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Version: 17.06d (Release date: 2017-06-26)
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Mannose-Binding Lectin (Code C1151)

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Terms & Properties

Preferred Name: Mannose-Binding Lectin

Definition: A recombinant protein similar or identical to human mannan-binding lectin (MBL) with opsonin activity. MBL, a soluble pattern recognition receptor (PRR) collectin in the C-type lectin superfamily, is a plasma protein that plays an important role in innate immunity; MBL contains a carbohydrate recognition domain at one end and a collagen-like stalk domain at the other. Upon MBL binding to mannose residues on mannose-containing polysaccharides (mannans) on the surfaces of microorganisms, activation of the complement system results in the deposition of complement components (opsonization) and the clearance of the opsonized microorganisms by phagocytic cells. MBL is part of the mannan-binding lectin pathway (also known as the Ali/Krueger pathway), which has similarities to the classical complement pathway in that activation of C4 and C2 produce activated complement proteins further down the complement cascade. However, unlike the classical complement pathway, activation of this pathway is not antibody dependent.

Display Name: Mannose-Binding Lectin

Label: Mannose-Binding Lectin

NCI Thesaurus Code: C1151 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831985  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Mannan-Binding Lectin
Mannose-Binding Lectin
Mannose Binding Protein
MBL
MBP
Recombinant Human Mannose-binding Lectin

External Source Codes: 
PDQ Closed Trial Search ID 486303
PDQ Open Trial Search ID 486303 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831985

Other Properties:
     Name Value (qualifiers indented underneath)
code C1151
Contributing_Source CTRP
Legacy_Concept_Name Mannose-Binding_Lectin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1151

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