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Version: 17.06d (Release date: 2017-06-26)
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Mafosfamide (Code C1150)

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Terms & Properties

Preferred Name: Mafosfamide

Definition: A synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely related to cyclophosphamide, mafosfamide, unlike cyclophosphamide, does not require hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide; accordingly, mafosfamide is potentially useful in the intrathecal treatment of neoplastic meningitis. (NCI04)

NCI-GLOSS Definition: A form of cyclophosphamide that can be administered as an intrathecal infusion. Mafosfamide is being studied as an anticancer drug. It belongs to the family of drugs called alkylating agents.

Label: Mafosfamide

NCI Thesaurus Code: C1150 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0065506  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Mafosfamide
mafosfamide
MAFOSFAMIDE

External Source Codes: 
CAS Registry Number 88859-04-5 (see NLM ChemIDplus info)
FDA UNII Code 5970HH9923
NSC Code 345842 (see NCI DTP info)
PDQ Closed Trial Search ID 41254
PDQ Open Trial Search ID 41254 (check for NCI PDQ open clinical trial info)
UMLS CUI C0065506

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H19Cl2N2O5PS2
code C1150
Contributing_Source FDA
Legacy_Concept_Name Mafosfamide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1150

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