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Version: 17.06d (Release date: 2017-06-26)
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Multi-epitope Folate Receptor Alpha-loaded Dendritic Cell Vaccine (Code C114990)

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Terms & Properties

Preferred Name: Multi-epitope Folate Receptor Alpha-loaded Dendritic Cell Vaccine

Definition: A cell-based vaccine composed of autologous-monocyte-derived dendritic cells (DCs) loaded with five immunogenic peptide epitopes, derived from the tumor-associated antigen human folate receptor alpha (FR alpha or FOLR1), including FR30, FR56, FR76, FR113, and FR238, with potential immunomodulatory and antineoplastic activity. Ex vivo treatment of the DCs with a p38 inhibitor decreases p38-mediated signaling and enhances ERK activation. This may allow, upon intradermal administration of the multi-epitope FR alpha-loaded DC vaccine into the patient, for decreased activation and expansion of CD4+ regulatory T-cells (Tregs), increased differentiation and expansion of interleukin-17 secreting T helper cells (Th17) and activation of CD8+ CTLs, which induces a strong anti-tumor T-cell immune response against FR alpha-overexpressing tumor cells. FR alpha is a high-affinity folate-binding protein and a member of the folate receptor family; this receptor is overexpressed in the majority of ovarian cancers and in about approximately 50% of breast cancers.

Display Name: Multi-epitope Folate Receptor Alpha-loaded Dendritic Cell Vaccine

Label: Multi-epitope Folate Receptor Alpha-loaded Dendritic Cell Vaccine

NCI Thesaurus Code: C114990 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3896672  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
FRaDC Vaccine
FRalphaDC Vaccine
Multi-epitope Folate Receptor Alpha-loaded Dendritic Cell Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 759503
PDQ Open Trial Search ID 759503 (check for NCI PDQ open clinical trial info)
UMLS CUI C3896672

Other Properties:
     Name Value (qualifiers indented underneath)
code C114990
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C114990

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