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Version: 17.06d (Release date: 2017-06-26)
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NS5B Polymerase Inhibitor BMS-791325 (Code C114983)

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Terms & Properties

Preferred Name: NS5B Polymerase Inhibitor BMS-791325

Definition: A non-nucleoside, polymerase inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B), a RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intracellular uptake, BMS-791325 allosterically binds to the non-catalytic Thumb 1 site of viral HCV NS5B polymerase and causes a decrease in viral RNA synthesis and replication. The HCV NS5B protein is essential for the replication of the viral HCV RNA genome. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family.

Label: NS5B Polymerase Inhibitor BMS-791325

NCI Thesaurus Code: C114983 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3852614  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BMS-791325
NS5B Polymerase Inhibitor BMS-791325

External Source Codes: 
PDQ Closed Trial Search ID 759585
PDQ Open Trial Search ID 759585 (check for NCI PDQ open clinical trial info)
UMLS CUI C3852614

Other Properties:
     Name Value (qualifiers indented underneath)
code C114983
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C114983

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