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Version: 17.06d (Release date: 2017-06-26)
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Daclatasvir (Code C114981)

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Terms & Properties

Preferred Name: Daclatasvir

Definition: An orally available inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A) replication complex, with potential activity against HCV. Although the exact mechanism of action of daclatasvir has yet to be fully determined, this agent, upon oral administration and after intracellular uptake, appears to bind to domain I of the NS5A protein. This inhibits the activity of the NS5A protein and results in the disruption of the viral RNA replication complex, blockage of viral HCV RNA production, and inhibition of viral replication. NS5A, a zinc-binding and proline-rich hydrophilic phosphoprotein, plays a crucial role in HCV RNA replication. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family.

Label: Daclatasvir

NCI Thesaurus Code: C114981 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2933824  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BMS-790052
Daclatasvir
DCV

External Source Codes: 
PDQ Closed Trial Search ID 759583
PDQ Open Trial Search ID 759583 (check for NCI PDQ open clinical trial info)
UMLS CUI C2933824

Other Properties:
     Name Value (qualifiers indented underneath)
code C114981
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C114981

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