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Version: 17.06d (Release date: 2017-06-26)
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MDM2 Antagonist RO6839921 (Code C114980)

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Terms & Properties

Preferred Name: MDM2 Antagonist RO6839921

Definition: An MDM2 (human homolog of murine double minute-2; HDM2) antagonist with potential antineoplastic activity. Upon intravenous administration, RO6839921 binds to MDM2 and prevents the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing MDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This may result in the restoration of p53 signaling, followed by p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein, is a negative regulator of the p53 pathway and is often overexpressed in cancer cells; p53 inhibition has been implicated in cancer cell proliferation and survival.

Label: MDM2 Antagonist RO6839921

NCI Thesaurus Code: C114980 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL472577  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MDM2 Antagonist RO6839921
RO6839921

External Source Codes: 
PDQ Closed Trial Search ID 759578
PDQ Open Trial Search ID 759578 (check for NCI PDQ open clinical trial info)
NCI META CUI CL472577

Other Properties:
     Name Value (qualifiers indented underneath)
code C114980
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C114980

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