skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
MAGE-A4-specific TCR Gene-transduced Autologous T Lymphocytes TBI-1201 (Code C114978)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: MAGE-A4-specific TCR Gene-transduced Autologous T Lymphocytes TBI-1201

Definition: Autologous human T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human melanoma antigen A4 (MAGE-A4), with potential immunostimulatory and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, MAGE-A4-specific TCR gene-transduced T-lymphocytes TBI-1201 binds to tumor cells expressing MAGE-A4. This may result in both an inhibition of growth and increased cell death for MAGE-A4-expressing tumor cells. The tumor-associated antigen MAGE-A4 is overexpressed by a variety of cancer cell types.

Label: MAGE-A4-specific TCR Gene-transduced Autologous T Lymphocytes TBI-1201

NCI Thesaurus Code: C114978 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL472575  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MAGE-A4-specific TCR Gene-transduced Autologous T Lymphocytes TBI-1201
TBI-1201

External Source Codes: 
PDQ Closed Trial Search ID 759543
PDQ Open Trial Search ID 759543 (check for NCI PDQ open clinical trial info)
NCI META CUI CL472575

Other Properties:
     Name Value (qualifiers indented underneath)
code C114978
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C114978

Mainbox Bottom