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Version: 17.06d (Release date: 2017-06-26)
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Iodine I 124-labeled Anti-PSCA A11 Minibody (Code C114501)

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Terms & Properties

Preferred Name: Iodine I 124-labeled Anti-PSCA A11 Minibody

Definition: A radioconjugate composed of an affinity-matured antibody fragment, the A11 minibody, directed against human prostate stem cell antigen (PSCA), and conjugated with the radioisotope iodine I 124, that can potentially be used as an imaging agent for positron emission tomography (PET)/computed tomography (CT). The minibody moiety of iodine I 124-labeled anti-PSCA A11 minibody selectively targets and binds to PSCA. The PSCA-expressing tumor cells can then be visualized using PET/CT. PSCA, a cell surface antigen expressed in normal human prostate and bladder, is overexpressed in a variety of cancers, including bladder, pancreatic, and prostate cancer. The A11 minibody is formed by the fusion of a single chain Fv fragment with the immunoglobulin G1 CH3 domain.

Display Name: Iodine I 124-labeled Anti-PSCA A11 Minibody

Label: Iodine I 124-labeled Anti-PSCA A11 Minibody

NCI Thesaurus Code: C114501 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL472326  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
124I-A11 PSCA Minibody
Iodine I 124-labeled Anti-PSCA A11 Minibody

External Source Codes: 
PDQ Closed Trial Search ID 759449
PDQ Open Trial Search ID 759449 (check for NCI PDQ open clinical trial info)
NCI META CUI CL472326

Other Properties:
     Name Value (qualifiers indented underneath)
code C114501
Contributing_Source CTRP
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C114501

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