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Version: 17.06d (Release date: 2017-06-26)
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IL-12-expressing Mesenchymal Stem Cell Vaccine GX-051 (Code C114385)

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Terms & Properties

Preferred Name: IL-12-expressing Mesenchymal Stem Cell Vaccine GX-051

Definition: Human mesenchymal stem cells (MSCs) transduced with a retroviral vector encoding a modified form of the cytokine interleukin-12 (IL-12), with potential immunomodulating and antineoplastic activities. Upon intratumoral administration, IL-12-expressing MSC vaccine GX-051 secretes IL-12. IL-12 activates the immune system by both promoting the secretion of interferon-gamma, which activates natural killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation and increased cell death in tumor cells.

Label: IL-12-expressing Mesenchymal Stem Cell Vaccine GX-051

NCI Thesaurus Code: C114385 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL471821  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GX-051
IL-12-expressing Mesenchymal Stem Cell Vaccine GX-051
MSCs/IL-12M

External Source Codes: 
PDQ Closed Trial Search ID 758797
PDQ Open Trial Search ID 758797 (check for NCI PDQ open clinical trial info)
NCI META CUI CL471821

Other Properties:
     Name Value (qualifiers indented underneath)
code C114385
Semantic_Type Cell

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C114385

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