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Version: 17.12d (Release date: 2017-12-26)
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IDH1 Inhibitor AG-120 (Code C114383)

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Terms & Properties

Preferred Name: IDH1 Inhibitor AG-120

Definition: An orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Upon administration, AG-120 specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells. IDH1, an enzyme in the citric acid cycle, is mutated in a variety of cancers; it initiates and drives cancer growth by both blocking cell differentiation and catalyzing the formation of 2HG.

Display Name: IDH1 Inhibitor AG-120

Label: IDH1 Inhibitor AG-120

NCI Thesaurus Code: C114383 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL471818  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IDH1 Inhibitor AG-120

External Source Codes: 
PDQ Closed Trial Search ID 758551
PDQ Open Trial Search ID 758551 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C114383
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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