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Version: 17.06d (Release date: 2017-06-26)
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Photosensitizer LUZ 11 (Code C114382)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Photosensitizer LUZ 11

Definition: A bacteriochlorin-based photosensitizer, with antineoplastic activity upon photodynamic therapy (PDT). Following intravenous administration, the photosensitizer LUZ 11 preferentially accumulates in hyperproliferative tissues, such as tumors. Local application of laser light at the tumor site results in the absorption of light by this agent and a photodynamic reaction between LUZ 11 and oxygen. This results in the production of reactive oxygen species (ROS), which includes singlet oxygen molecules, the superoxide ion, and other cytotoxic free radicals. The formation of ROS induces free radical-mediated DNA damage and cell death.

Label: Photosensitizer LUZ 11

NCI Thesaurus Code: C114382 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL471817  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
LUZ 11
Photosensitizer LUZ 11

External Source Codes: 
PDQ Closed Trial Search ID 758537
PDQ Open Trial Search ID 758537 (check for NCI PDQ open clinical trial info)
NCI META CUI CL471817

Other Properties:
     Name Value (qualifiers indented underneath)
code C114382
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C114382

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