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Version: 17.06d (Release date: 2017-06-26)
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Glutaminase Inhibitor CB-839 (Code C114381)

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Terms & Properties

Preferred Name: Glutaminase Inhibitor CB-839

Definition: An orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Upon oral administration, CB-839 selectively and irreversibly inhibits glutaminase, a mitochondrial enzyme that is essential for the conversion of the amino acid glutamine into glutamate. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival.

Display Name: Glutaminase Inhibitor CB-839

Label: Glutaminase Inhibitor CB-839

NCI Thesaurus Code: C114381 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3827146  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Glutaminase Inhibitor CB-839

External Source Codes: 
PDQ Closed Trial Search ID 758477
PDQ Open Trial Search ID 758477 (check for NCI PDQ open clinical trial info)
UMLS CUI C3827146

Other Properties:
     Name Value (qualifiers indented underneath)
code C114381
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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