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Version: 17.06d (Release date: 2017-06-26)
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DNR-expressing Nasopharyngeal Carcinoma-specific Cytotoxic T-Lymphocytes (Code C114378)

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Terms & Properties

Preferred Name: DNR-expressing Nasopharyngeal Carcinoma-specific Cytotoxic T-Lymphocytes

Definition: A preparation of autologous, dominant-negative receptor (DNR)-expressing nasopharyngeal carcinoma (NPC)-specific cytotoxic T-lymphocytes (CTLs), with potential antineoplastic activity. The DNR-expressing NPC-specific CTLs specifically target Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1), latent membrane proteins (LMP) and BamHIA rightward frame 1 (BARF1), and are transduced with a retroviral vector expressing DNR, a dominant-negative form of the transforming growth factor beta (TGFb) receptor, which blocks TGF-beta-mediated signaling. Upon administration, the CTLs recognize and target NPC cells, which may result in both CTL-mediated cell lysis and the inhibition of tumor cell proliferation. Tumor-expressed TGF-beta inhibits T-lymphocyte activation and expansion; resistance to TGF-beta allows for optimal CTL activity. EBV infection plays a key role in NPC tumorigenesis.

Label: DNR-expressing Nasopharyngeal Carcinoma-specific Cytotoxic T-Lymphocytes

NCI Thesaurus Code: C114378 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL471809  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DNR-expressing Nasopharyngeal Carcinoma-specific Cytotoxic T-Lymphocytes
DNR NPC-specific CTLs

External Source Codes: 
PDQ Closed Trial Search ID 758353
PDQ Open Trial Search ID 758353 (check for NCI PDQ open clinical trial info)
NCI META CUI CL471809

Other Properties:
     Name Value (qualifiers indented underneath)
code C114378
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C114378

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