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Version: 17.06d (Release date: 2017-06-26)
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IL-12-expressing HSV-1 (Code C114294)

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Terms & Properties

Preferred Name: IL-12-expressing HSV-1

Definition: A genetically engineered, replication selective, infected cell protein (ICP) 34.5 gene-deleted, oncolytic human simplex virus type 1 (HSV-1) expressing the human immunostimulating cytokine interleukin-12 (IL-12), with potential antineoplastic activity. Upon intratumoral administration of HSV-1 expressing IL-12, the IL-12-expressing HSV-1 preferentially infects and replicates in tumor cells of neuronal origin causing viral-mediated tumor cell lysis. The released virus particles, in turn, infect and replicate in neighboring tumor cells. In addition, the IL-12-expressing HSV-1 promotes the secretion of IL-12 by the tumor cells. IL-12 promotes the activation of natural killer cells, which induces both the secretion of interferon-gamma and a cytotoxic T-lymphocyte (CTL) response against the tumor cells. This results in both immune-mediated tumor cell death and further inhibition of tumor cell proliferation. Deletion of the gene encoding for ICP34.5 imparts tumor selectivity by preventing replication in healthy cells.

Display Name: IL-12-expressing HSV-1

Label: IL-12-expressing HSV-1

NCI Thesaurus Code: C114294 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL471805  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IL-12-expressing HSV-1
NSC 733972

External Source Codes: 
PDQ Closed Trial Search ID 758218
PDQ Open Trial Search ID 758218 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C114294
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance
Semantic_Type Virus

Additional Concept Data: 
Defined Fully by Roles: No  


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