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Version: 17.06d (Release date: 2017-06-26)
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HER2-pulsed Autologous Type-1 Polarized Dendritic Cell Vaccine (Code C114293)

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Terms & Properties

Preferred Name: HER2-pulsed Autologous Type-1 Polarized Dendritic Cell Vaccine

Definition: A dendritic cell (DC)-based cancer vaccine composed of autologous, type-1 polarized dendritic cells (DCs) pulsed with human leukocyte antigen (HLA)-A2-restricted HER-2-derived peptides, with potential immunomodulatory and antineoplastic activities. Autologous DCs were treated with GM-CSF, interleukin-4, interferon-gamma and bacterial lipopolysaccharide (LPS), a toll-like receptor type 4 agonist, to produce highly polarized DCs (alphaDC1) that are capable of producing high levels of interleukin-12p70 (IL-12p70). Upon administration, HER2-pulsed autologous DC vaccine may stimulate a potent cytotoxic T-lymphocyte (CTL) response against HER-2-positive tumor cells, which may result in tumor cell death and decreased tumor growth. HER-2, a tyrosine kinase receptor for epidermal growth factor (EGF) (also known as neu and ErbB2), is overexpressed by a variety of cancers.

Label: HER2-pulsed Autologous Type-1 Polarized Dendritic Cell Vaccine

NCI Thesaurus Code: C114293 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL472222  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HER-2 pulsed DC1 Vaccine
HER2-pulsed Autologous Type-1 Polarized Dendritic Cell Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 758205
PDQ Open Trial Search ID 758205 (check for NCI PDQ open clinical trial info)
NCI META CUI CL472222

Other Properties:
     Name Value (qualifiers indented underneath)
code C114293
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C114293

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