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Version: 17.06d (Release date: 2017-06-26)
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H1299 Tumor Cell Lysate Vaccine (Code C114284)

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Terms & Properties

Preferred Name: H1299 Tumor Cell Lysate Vaccine

Definition: A cell lysate derived from a lung cancer cell line, H1299, with potential immunostimulatory and antineoplastic activities. Upon intramuscular administration, the H1299 tumor cell lysate exposes the immune system to an undefined amount of tumor associated antigens (TAA), particularly cancer testis antigens (CTAs), which may result in the induction of both anti-tumoral cytotoxic T-lymphocytes (CTL) and antibody-dependent responses against TAA-expressing cells, leading to tumor cell lysis. CTAs, such as MAGE, are selectively expressed in a variety of cancers but are not expressed in normal, healthy cells outside the testis.

Label: H1299 Tumor Cell Lysate Vaccine

NCI Thesaurus Code: C114284 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL471792  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
H1299 Lysate Vaccine
H1299 Tumor Cell Lysate Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 757927
PDQ Open Trial Search ID 757927 (check for NCI PDQ open clinical trial info)
NCI META CUI CL471792

Other Properties:
     Name Value (qualifiers indented underneath)
code C114284
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C114284

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